Lilly COVID-19 treatment could be authorized for use as soon as September: Chief scientist

first_imgCoronavirus vaccines being developed and tested at unprecedented speed are not likely to be ready before the end of the year at the earliest.Earlier this month, Lilly announced it had initiated patient testing for two separate antibody treatments. One currently designated LY-CoV555 is being developed in partnership with Canadian biotech AbCellera. The other, JS016, it being developed with Chinese drugmaker Shanghai Junshi Biosciences.Both work by blocking part of the virus’ so-called spike protein that it uses to enter human cells and replicate.Lilly’s third antibody treatment candidate acts on a different part of the virus and will most likely be tested in combination with one or both of the others, Skovronsky said.The drugmaker, however, said it has a strong preference to develop a treatment that can work well in COVID-19 patients as a stand alone, as manufacturing these type of drugs, which are typically administered by infusion, is a complex process and capacity is limited.”It’s good to have two antibodies. The downside is that manufacturing is precious. We have limited manufacturing capacity. If two antibodies are required, half as many people will get treated,” Skovronsky said. “So our goal is to see if we can do one antibody at as low a dose as possible.”Lilly will have the capacity to make hundreds of thousands of doses by the end of the year if it can treat COVID-19 patients using a single antibody drug rather than with a combination, he said.Preventing the disease with these type of drugs presents a different manufacturing challenge entirely.”Global capacity for antibodies is just not high enough that we could ever think about adequate doses” for “billions of people in the prophylactic setting,” Skovronsky said.The better solution is to widely inoculate people with COVID-19 vaccines when available, and reserve antibody treatments for people who have the disease or were recently exposed to it.They could also help vulnerable populations where vaccines are less effective, such as nursing home patients, he said.Lilly hopes to conduct a COVID-19 prevention clinical trial in nursing home patients later this year, he added.The Indianapolis-based drugmaker plans to produce the medicines in plants in Kinsale, Ireland and New Jersey, and is willing to use its capacity to help manufacture another company’s successful treatment, should Lilly’s fail in clinical trails.Lilly is continuing to screen for antibodies through its partnership with AbCellera, which is working with the US National Institutes of Health to identify promising compounds, Skovronsky said.  Eli Lilly and Co could have a drug specifically designed to treat COVID-19 authorized for use as early as September if all goes well with either of two antibody therapies it is testing, its chief scientist told Reuters on Wednesday.Lilly is also doing preclinical studies of a third antibody treatment for the illness caused by the new coronavirus that could enter human clinical trials in the coming weeks, Chief Scientific Officer Daniel Skovronsky said in an interview.Lilly has already launched human trials with two of the experimental therapies. Topics :center_img The drugs belong to a class of biotech medicines called monoclonal antibodies widely used to treat cancer, rheumatoid arthritis and many other conditions. A monoclonal antibody drug developed against COVID-19 is likely to be more effective than repurposed medicines currently being tested against the virus.Skovronsky said the therapies – which may also be used to prevent the disease – could beat a vaccine to widespread use as a COVID-19 treatment, if they prove effective.”For the treatment indication, particularly, this could go pretty fast,” he said in an interview. “If in August or September we’re seeing the people who got treated are not progressing to hospitalization, that would be powerful data and could lead to emergency use authorization.””So that puts you in the fall time: September, October, November is not unreasonable,” he said.last_img read more

Estol George Bodenberg

first_imgA lifelong resident of the Napoleon/Osgood area, Estol George Bodenberg, age 75 passed away early Friday, June 9, at his home surrounded by his family. Estol was born on November 30, 1941, the son of the late Clarence and Alma (Fruchtnicht) Bodenberg on the home farm outside of Napoleon.  Estol grew up with 3 sisters and 1 brother, learning early on that family matters.He attended Napoleon High School and graduated in the class of 1959.  After school he was called to serve his country and was drafted into the Army in 1964.  His service lasted 2 years, seeing time spent from Fort Knox to Okinawa. He returned to the farm after the service, and began his work career.  He was raised in a generation where you worked hard   and provided for your family.  He spent nearly 40 years working as a factory employee at BCA in Greensburg and working long hours on his parent’s farm.  He was a faithful member of St John’s Lutheran Church and served various terms as a council member.Estol met Janet (Amm) of Sunman and was united in marriage on May 11, 1968 at St. Jacob Church of Christ in Sunman, and recently celebrated their 49th wedding anniversary.  Estol and Janet later purchased the farm and built a new home just south of the original homestead.  Estol and Janet were blessed with a daughter, Beth Ann (Brian) Heilers now of Indianapolis and son, Steve (Meghan) Bodenberg of Carmel.  He instilled a strong work ethic, faith, honesty and family values in his children.Estol is survived by his wife Janet, daughter Beth Ann and son Steve;  grandchildren Claire, Natalie, Nathan, and Anna; brother Dave Bodenberg; sisters Alice Huffmeyer, Eileen Knigga, and Emma Lou Menchhofer.Visitation will be Sunday, June 11, 2017 at Neal’s Funeral Home in Osgood from 3:00 pm- 6:00 pm.  Funeral services will be held Monday, June 12, 2017 at 10:00 am. at St John’s Lutheran Church in Napoleon with doors opening at 9:00 am.  Memorials may be made to St John’s Lutheran Church in care of the funeral home.last_img read more

Paul Pogba nutmegs mum during playful kickabout

first_img Promoted Content5 Reasons Why The Black Widow Solo Movie Will Be AwesomeWhich Country Is The Most Romantic In The World?Can Playing Too Many Video Games Hurt Your Body?Birds Enjoy Living In A Gallery Space Created For Them5 Of The World’s Most Unique Theme ParksHere Are The Best Movies Since 1982 You Should Definitely SeeA Hurricane Can Be As Powerful As 10 Atomic BombsYou’ve Only Seen Such Colorful Hairdos In A Handful Of AnimePlaying Games For Hours Can Do This To Your Body8 Addictive And Fun Coffee Facts6 Ridiculous Health Myths That Are Actually TrueThe 90s Was A Fantastic Decade For Fans Of Action Movies Manchester United star Paul Pogba showed “no mercy” as he nutmegged his mum while out for a walk.Advertisement And he decided to have a bit of fun with his mother Yeo Moriba on exercise from coronavirus lockdown.Pogba kept close control of the ball as Yeo advanced towards him.The footballer spots the opening and makes his moveIn truth the nutmeg was a bit lucky as the ball squeezed through his mum’s ankles, with both left laughing at the outcome.And the former Juventus midfielder had a loving message as he uploaded the clip to his Instagram account.It was touch and go, but Pogba manages to eventually squeeze the ball throughThe 26-year-old captioned it: “When your mum tells you she played football before“Love and spend time with your parents before they leave the world.”The French footballer described the move as ‘no mercy’ when he uploaded it to InstagramHe then added the hashtags “nomercy” and “sonvsmum” to the post.Several people commented with the “flame” emoji, while another begged him to “sign a new contract at United”.Mother and son were in fits of laughter at how the nutmeg eventually came aboutRead Also: UEFA urges leagues to complete suspended football seasonsThe French international’s future at Old Trafford remains unclear after numerous disagreement between his agent Mino Raiola and club execs.But United captain Harry Maguire believes the future could be bright for Pogba at United – thanks to new signing Bruno Fernandes.FacebookTwitterWhatsAppEmail分享 The French midfielder showed how much he is missing the Beautiful Game by taking a football outside with him. Loading… last_img read more

Lady Eagles And Lady Chargers Win Middle School Conference Championships

first_imgThe 8th Grade JCD Lady Eagles were named Champions of the ORVC Tourney on Saturday.  The Eagles came out strong to defeat Switzerland County in the first game 38-28.  Scoring for the lady Eagles were Reagan Hughes 19, Reese Obendorf 10, Emma Wagner 5, Julia Meyer 4.  JCD came out to play Southwestern Hanover for the championship game.  The Eagles moved the ball well and played solid defense to win the game 41-26.  Scoring for the Lady Eagles were Julia Meyer 12, Reese Obendorf 11, Reagan Hughes 10, Emma Wagner 4, Kinsey Rohls 4.  Courtesy of Eagles Scorekeeper Brandy Meyer.  The North Decatur Lady Chargers win The MHC Crown by defeating The South Decatur Lady Cougars 39-35. In true fashion the North vs South rivalry did not disappoint. In an up and down game, the girls on both sides of the bench played their hearts out. Congrats to SD on a great season. The Lady Chargers once again were led by Hannah Gorrell who had a career day with 15 points including 3 three balls and 2-2 from the line. Following her was Kasey Barker with 10 points. Kelsey Haley added 8 with 2 triples. Madi Allen was 4-6 at the line finishing with 6 points. As a side note to the historic season….. what a privilege and honor it has been for me to be a part of this program. Thanks go out to all the parents, coaches, faculty, and staff of North Decatur. #CHARGERPRIDEThe Lady Chargers had one goal for this game and that was to leave no doubt that they were advancing to the conference championship game defeating Hauser 60-17. Stellar defense coupled with lights out shooting were keys to success. Brooke Mauer had 4 rebounds and 3 assists. Hannah Gorrell led all scorers with 17 including 3 from downtown and 4-4 from the line. Madi Allen followed with 14 points and was 6-8 on free throws. Emma Schoettmer caught fire in the 4th quarter knocking in 7. Kylie Duckworth and Kacey Barker each added 6. Ally Whitaker and Kelsey Haley each had 3, all from the charity stripe. Gabi Adams and Laney Saunders both had 2 in the 2nd quarter. The Chargers moved to 17-0 on the season.Courtesy of Chargers Coach Eric Whitaker.last_img read more